A comprehensive review on invasomal carriers incorporating natural terpenes for augmented transdermal delivery

Abstract Background Transdermal drug delivery is one of the most widely used administration routes, which offer several advantages over other routes delivery. The apical layer skin called stratum corneum dominant obstacle in transdermal delivery, restricts passage drugs across skin. Considerable strategies have been applied to enhance rate permeation epithelial cells; however, strategy use sorption boosters, also known as enhancers. Main body Terpenes were considered efficient enhancers and are generally recognized safe per Food Drug Administration. improve permeability either by destructing ’s tightly packed lipid framework, excessive diffusivity cell membrane or rampant partitioning into cells. Various vesicular systems developed utilized for many drugs. Invasomes such novel system composed phospholipids, ethanol terpenes. combined presence terpenes provides exceptional flexibility vesicles improves barrier offered due both act Therefore, utilization invasomes carriers facilitate higher through can be a very useful approach drug. Conclusion paper focuses on broad updated view effective along with their applications pharmaceutical formulations.